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Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis: A Randomized Controlled Trial

January 9, 2013

Timothy McAlindon, DM, MPH; Michael LaValley, PhD; Erica Schneider, PhD; Melynn Nuite, RN, BS; Ji Yeon Lee, MD, MSc; Lori Lyn Price, MAS; Grace Lo, MD, MSc; Bess Dawson-Hughes, MD

Importance Knee osteoarthritis (OA), a disorder of cartilage and periarticular bone, is a public health problem without effective medical treatments. Some studies have suggested that vitamin D may protect against structural progression.

Objective

To determine whether vitamin D supplementation reduces symptom and structural progression of knee OA...

...Conclusion and Relevance

Vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL, when compared with placebo, did not reduce knee pain or cartilage volume loss in patients with symptomatic knee OA.